|
Zinc deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased NF-kappaB activation in HUT-78 due to zinc deficiency was due to decreased binding of NF-kappaB to DNA, decreased level of NF-kappaB p105 (the precursor of NF-kappaB p50) mRNA, decreased kappaB inhibitory protein (IkappaB) phosphorylation, and decreased Ikappa kappa.
|
18385818 |
2008 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Well-differentiated papillary mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors.
|
30171198 |
2019 |
|
Well Differentiated Pancreatic Endocrine Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although the frequencies of I and D alleles and genotype distribution did not differ between the study and control groups, there seem to be important differences concerning the DD genotype analyses of the NFKB1 -94ins/delATTG promoter polymorphism between patients with pancreatic neuroendocrine tumor and those with carcinoid tumor.
|
19752553 |
2009 |
|
Virus Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Deregulation of microRNA-155 and its transcription factor NF-kB by polychlorinated biphenyls during viral infections.
|
29380441 |
2018 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Virus infection does not appear to alter the amount of RelA (p65) or NFKB1 (p50) but rather affects the capacity of I kappa B alpha to sequester RelA (p65), therefore leading to constitutive levels of RelA DNA binding activity and to increased levels of NF-kappa B-dependent gene activity.
|
8394446 |
1993 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Chromatin immunoprecipitation experiments indicated that binding of NFkappaB p65 and p50 subunits to the IL-8 promoter upon viral infection was differentially reduced by chemical inhibitors of MAPKs.
|
20038977 |
2009 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
The human TLR3 isoform in human iPSC-NSC functions to suppress NF-KB p65 signaling pathway in response to virus (Poly IC), suggesting suppressed immunity of iPSC-derived cells to viral infection.
|
30664289 |
2019 |
|
Virus Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Effect of active compounds on NF-kB and MAPK signaling pathways after virus infection was determined by ELISA.
|
29157813 |
2017 |
|
Virus Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Activation of NF-kB and STAT-3 most likely contribute to the progression of viral infections to chronic hepatitis and liver oncogenesis associated with HBV and HCV infections.
|
12734409 |
2003 |
|
Viral myocarditis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Results indicated that andrographolide treatment reduced serum levels of TNF-α, hs-CRP and cTnl, increased the expression levels of IL-10 and STAT3 and reduced the expression levels of NF-κβ p65 and NF-κβ p50 and the phosphorylation levels of phosphoinositide 3-kinase (P13K) and AKT in the heart tissues of mice with VMC.
|
30186451 |
2018 |
|
Venous Thromboembolism
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In patients who received prophylaxis with low dose aspirin a single-nucleotide polymorphism in NFκB1 (rs3774968) gene was associated with increased risk of VTE (OR 3.76, 95%CI 1-16, P = 0.051).
|
23757261 |
2013 |
|
Vasculitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Since GCA is a polygenic disease, we sought to assess the potential role of the -94ins/delATTG NFKB1 promoter polymorphism in susceptibility to GCA and to determine if this polymorphism is implicated in the clinical expression of this vasculitis.
|
16465659 |
2006 |
|
Vasculitis
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Variable expressivity
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Uveal melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Activation of NFκB1/p50 was evaluated in 75 cases of uveal melanoma by immunohistochemistry. mRNA expression in 58 fresh UM specimen was measured by quantitative reverse-transcriptase PCR (qRT-PCR).
|
31533021 |
2019 |
|
Urothelial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PINA4MS app in cytoscape revealed over expression of RelA and suppression of NF-κB1 (p50 precursor) in UC whereas the expression of NF-κB target proteins remained unhindered.
|
30225173 |
2018 |
|
Uric acid measurement (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We tested the function of NF-κB1 in an acute (nephrotoxic serum (NTS) nephritis) and a chronic (unilateral ureteric obstruction (UUO)) model of renal injury using NF-κB1 (nfκb1<sup>-/-</sup>) knockout mice.
|
28617440 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis.
|
14613970 |
2004 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations involving the NF-kB pathway and epigenetic regulation were more common in ulcerative colitis-associated CRCs than in sporadic CRCs.
|
30794281 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC).
|
18716880 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of 3 candidate genes (PTPN22, NFkB1, and FcGRIIIA) were investigated in 649 IBD patients (343 with Crohn's disease [CD] and 306 with ulcerative colitis [UC]), 176 unaffected relatives, and 256 healthy controls.
|
17600378 |
2007 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
|
17124531 |
2006 |